Clinical Research Clinical outcome of Extramedullary plasmacytomas in multiple myeloma

This study is retrospective investigation of extramedullary plasmacytomas(EMPs) in patients with multiple myeloma (MM ) . The main purpose is to discuss the clinical characteristics and treatment. Method:We studied 79 patients of EMP in MM, and collected the clinical characteristics, laboratory features, treatment, and prognosis of extramedullary plasmacytoma(EMP) in patients with multiple myeloma(MM). Pataints were divided into two groups: group 1 included 32 patients who developed EMP during the course of MM; group 2 included 47 patients who had EMP at the time of MM diagnosis.Result: The median patient age was 56.2 years, with a male/female ratio of 45:34. MM cells can invade all parts of the body. The most common sites for EMP were soft tissues(50 patients), spinal canal (36 patients). The median survival duration of the two groups was 33.6 months (range: 8–96 months) and 21 months (range: 1–52 months) respectively.Especially for 2 groups,is less than the average survival time 3-5 years with the comparison to the patients who were not combinated with EMP. Conclusion:The occurrence of EMPs in patients with MM is associated with poor outcomes.